Lifshitz K, Lee K L, Susswein S
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, N.Y.
Neuropsychobiology. 1987;18(4):205-11. doi: 10.1159/000118419.
The spectral characteristics and average, auditory evoked potentials (AEPs) were determined from EEGs repeatedly recorded over a span of several years. Data from a vertex lead is presented for 4 chronic schizophrenic patients and 5 normal subjects. Measurements were made under identical conditions. For each subject characteristic spectra and AEPs were exhibited despite the passage of time. Patients had recordings performed both on and off antipsychotic medication. While receiving antipsychotic medication the patients' EEG spectra showed an increase in alpha activity. Less consistently there was a decrease in delta or an increase in beta activity; theta activity was unchanged. These latter effects are different from those generally reported for an acute antipsychotic dose and may be more representative of antipsychotic effects (which occur after days or weeks of treatment). Psychopathology tended to be inversely related to alpha power, the magnitude of the AEP N100, and medication.
在数年时间跨度内多次记录脑电图（EEG），以确定其频谱特征以及平均听觉诱发电位（AEP）。给出了4名慢性精神分裂症患者和5名正常受试者的头顶导联数据。测量是在相同条件下进行的。尽管时间流逝，但每个受试者的特征频谱和AEP均表现出来。患者在服用和未服用抗精神病药物时都进行了记录。在服用抗精神病药物期间，患者的脑电图频谱显示α活动增加。不太一致的是，δ活动减少或β活动增加；θ活动未改变。后一种效应与急性抗精神病药物剂量通常报告的效应不同，可能更能代表抗精神病药物的效应（在治疗数天或数周后出现）。精神病理学倾向于与α功率、AEP N100的幅度以及药物治疗呈负相关。
