Ford J M, White P M, Csernansky J G, Faustman W O, Roth W T, Pfefferbaum A
Department of Veterans Affairs Medical Center, Palo Alto, CA 94304.
Biol Psychiatry. 1994 Aug 1;36(3):153-70. doi: 10.1016/0006-3223(94)91221-1.
Thirty unmedicated schizophrenics were compared to 29 age-matched controls on auditory and visual event-related brain potential (ERP) paradigms. Twenty-one of these patients were tested again after 1 week on placebo and after 4 weeks on antipsychotic medication. Before treatment, N1, N2, and P3 components of the auditory ERP were smaller in the schizophrenics than in the controls. Although visual N2 was smaller in schizophrenics, visual P3 was not. In spite of significant clinical improvement with antipsychotic treatment, amplitudes of auditory and visual N1, N2, and P3 were not significantly changed. Higher blood levels of antipsychotic medication were related to reductions in auditory P3 latency, however. In addition, higher levels of cerebrospinal fluid (CSF) MHPG (methoxyhydroxyphenylglycol) were associated with larger auditory N1s and larger auditory and visual P3s, suggesting an influence of arousal on these components in schizophrenics. In spite of this influence, reduction of the auditory P3 in schizophrenia is an enduring trait of the disease, which is not affected by antipsychotic medication or clinical improvement.
在听觉和视觉事件相关脑电位（ERP）范式下，对30名未接受药物治疗的精神分裂症患者与29名年龄匹配的对照组进行了比较。其中21名患者在服用安慰剂1周后以及服用抗精神病药物4周后再次接受测试。治疗前，精神分裂症患者听觉ERP的N1、N2和P3成分比对照组小。虽然精神分裂症患者的视觉N2较小，但视觉P3并非如此。尽管抗精神病治疗使临床症状有显著改善，但听觉和视觉N1、N2和P3的波幅并无显著变化。然而，抗精神病药物的血药浓度升高与听觉P3潜伏期缩短有关。此外，脑脊液（CSF）中较高水平的MHPG（甲氧基羟基苯乙二醇）与较大的听觉N1以及较大的听觉和视觉P3相关，这表明觉醒对精神分裂症患者的这些成分有影响。尽管有这种影响，但精神分裂症患者听觉P3的降低是该疾病的一个持久特征，不受抗精神病药物或临床改善的影响。
