Page D V, Brady K, Mitchell J, Pehrson J, Wade G
Department of Pathology, Boston University School of Medicine, Massachusetts.
Obstet Gynecol. 1988 Sep;72(3 Pt 2):479-81.
The autopsy findings are described in two infants of hyperthyroid mothers in whom the clinical symptomatology, laboratory data, and autopsy findings strongly suggested intrauterine thyrotoxicosis secondary to transplacental thyroid-stimulating immunoglobulin. Documented intrauterine thyrotoxicosis is extremely rare, and we believe these to be the first detailed pathologic descriptions of the entity. Autopsy findings included slim habitus, massive thyromegaly, hypertrophic cardiomegaly, congestive visceromegaly, pulmonary hypertension, adenopathy, and prominent amniotic fluid aspiration. Both cases illustrate the positive contribution that a carefully performed autopsy, even in the severely macerated stillborn, can make toward better understanding of intrauterine disease.
本文描述了两例母亲患有甲状腺功能亢进的婴儿的尸检结果。这两名婴儿的临床症状、实验室数据及尸检结果强烈提示，他们患有因经胎盘传递的甲状腺刺激免疫球蛋白所致的子宫内甲状腺毒症。有记录的子宫内甲状腺毒症极为罕见，我们认为这是对该病症的首批详细病理学描述。尸检结果包括体型消瘦、甲状腺肿大、心脏肥厚性扩大、内脏充血性肿大、肺动脉高压、腺病以及羊水吸入显著。这两个病例均表明，即使是对严重浸软的死产儿进行仔细的尸检，也有助于更好地了解子宫内疾病。
