破伤风诱导的细胞外钙减少与长时程增强之间的定量相关性。

Quantitative correlation between tetanus-induced decreases in extracellular calcium and LTP.

作者信息

Melchers B P, Pennartz C M, Wadman W J, Lopes da Silva F H

机构信息

Department of General Zoology, University of Amsterdam, The Netherlands.

出版信息

Brain Res. 1988 Jun 28;454(1-2):1-10. doi: 10.1016/0006-8993(88)90798-6.

DOI:10.1016/0006-8993(88)90798-6

PMID:2900660

Abstract

Decreases in the extracellular calcium concentration ([Ca2+]o), induced by tetanization of the Schaffer collaterals in rat hippocampal slices, were measured by means of Ca2+-sensitive microelectrodes. The amount of long term potentiation (LTP) of the evoked field potentials, induced by this tetanus, was determined. A positive correlation was found between the amplitude of the tetanus induced decrease in [Ca2+]o and the amount of LTP that was elicited. The N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-phosphonovalerate decreased both the tetanus-induced decreases in [Ca2+]o and the amount of LTP that was induced. We conclude that the amount of Ca2+ that enters the cell during a tetanus is of major importance in the induction process of LTP.

摘要

通过Ca²⁺敏感微电极测量大鼠海马切片中Schaffer侧支强直刺激诱导的细胞外钙浓度（[Ca²⁺]o）降低。测定了该强直刺激诱发的场电位长时程增强（LTP）的量。发现强直刺激诱导的[Ca²⁺]o降低幅度与诱发的LTP量之间呈正相关。N-甲基-D-天冬氨酸（NMDA）受体拮抗剂2-氨基-磷酸戊酸降低了强直刺激诱导的[Ca²⁺]o降低以及诱导的LTP量。我们得出结论，强直刺激期间进入细胞的Ca²⁺量在LTP的诱导过程中至关重要。