Clark D W, Smith G N, Patrick J, Richardson B, Brien J F
Department of Pharmacology and Toxicology, Faculty of Medicine, Queen's University, Kingston, Ontario, Canada.
Drug Metab Dispos. 1988 May-Jun;16(3):464-8.
The effect of short term maternal ethanol administration on the disposition of ethanol in the ovine maternal-fetal unit was determined. Eleven conscious instrumented near-term pregnant ewes (between 125 and 134 days of gestation; term, 147 days) received 1-hr iv infusion of 1 g of ethanol.kg of maternal body weight-1.day-1 for six days (N = 6 ewes) or an equivalent volume of saline for six days (N = 5 ewes). On the seventh day, the ethanol- and saline-pretreated animals were administered 1 g of ethanol.kg of maternal body weight-1. Ethanol and acetaldehyde concentrations were determined by headspace GLC in maternal blood, fetal blood, and amniotic fluid samples obtained at selected times during the 14-hr study. The data demonstrated that short term maternal administration of once-daily moderate dose ethanol did not produce major changes in the disposition of ethanol and its proximate metabolite, acetaldehyde, in the maternal, fetal, and amniotic fluid compartments during near-term ovine pregnancy.
确定了短期母体给予乙醇对绵羊母胎单位中乙醇处置的影响。11只清醒且装有仪器的近足月怀孕母羊（妊娠125至134天；足月为147天）接受为期6天的静脉输注，每天1小时，剂量为1克乙醇·千克母体体重⁻¹（N = 6只母羊），或为期6天输注等量体积的生理盐水（N = 5只母羊）。在第7天，给接受乙醇预处理和生理盐水预处理的动物给予1克乙醇·千克母体体重⁻¹。在14小时的研究期间，在选定时间采集母体血液、胎儿血液和羊水样本，通过顶空气相色谱法测定乙醇和乙醛浓度。数据表明，在近足月绵羊妊娠期间，短期母体每天给予一次中等剂量乙醇，并未使母体、胎儿和羊水腔室中乙醇及其直接代谢产物乙醛的处置产生重大变化。
