Davidson B, Kurstjens N P, Patton J, Cantrill R C
Department of Medical Biochemistry, University of the Witwatersrand Medical School, Johannesburg, South Africa.
Eur J Pharmacol. 1988 May 10;149(3):317-22. doi: 10.1016/0014-2999(88)90662-0.
We have used a classical neurotransmitter release model to investigate the effect of dietary polyenoic fatty acids on the sensitivity of the presynaptic dopamine autoreceptor in slices of cat caudate nucleus. Maximum inhibition of [3H]dopamine release was seen only in animals fed a diet containing post delta-6-desaturation fatty acids of both the w3 and w6 series. The removal of either or both groups of fatty acids resulted in attenuation of sensitivity of the autoreceptor to apomorphine. We propose that a balance of w3 and w6 fatty acids is required to maintain normal dopaminergic function in the cat caudate nucleus.
我们使用经典的神经递质释放模型，研究了膳食多不饱和脂肪酸对猫尾状核切片中突触前多巴胺自身受体敏感性的影响。仅在喂食含有ω3和ω6系列δ-6-去饱和后脂肪酸饮食的动物中，观察到了[3H]多巴胺释放的最大抑制。去除其中一组或两组脂肪酸都会导致自身受体对阿扑吗啡的敏感性减弱。我们提出，需要ω3和ω6脂肪酸的平衡来维持猫尾状核中正常的多巴胺能功能。
