Hertz L, Drejer J, Schousboe A
Dept. of Pharmacology, Univ. of Saskatchewan, Saskatoon, Canada.
Neurochem Res. 1988 Jul;13(7):605-10. doi: 10.1007/BF00973275.
Several aspects of energy metabolism (glucose utilization, lactate production, 14CO2 production from labeled glucose, glutamate or pyruvate, oxygen consumption and contents of ATP and phosphocreatine) were measured in cerebellar granule cells (glutamatergic) in primary cultures and compared with corresponding data for cerebral cortical neurons (mainly GABA-ergic) and astrocytes. Cerebellar granule cells and astrocytes were metabolically more active than cerebral cortical neurons. Glutamate which is utilized as a major metabolic fuel as astrocytes and, to a lesser extent, in cerebral cortical neurons, was virtually not oxidized in cerebellar granule cells.
在原代培养的小脑颗粒细胞（谷氨酸能）中测量了能量代谢的几个方面（葡萄糖利用、乳酸生成、标记葡萄糖、谷氨酸或丙酮酸生成的14CO2、氧气消耗以及ATP和磷酸肌酸含量），并与大脑皮质神经元（主要是γ-氨基丁酸能）和星形胶质细胞的相应数据进行了比较。小脑颗粒细胞和星形胶质细胞在代谢上比大脑皮质神经元更活跃。在星形胶质细胞以及在较小程度上在大脑皮质神经元中作为主要代谢燃料被利用的谷氨酸，在小脑颗粒细胞中几乎不被氧化。
