Sones K R, Njogu A R, Holmes P H
RMB Animal Health Ltd., Dagenham, Essex, England.
Acta Trop. 1988 Jun;45(2):153-64.
The sensitivities of 3 strains of Trypanosoma congolense to isometamidium chloride (Samorin) were determined in mice and cattle, with the objective of evaluating sensitivity testing in mice as a means of predicting curative doses in cattle. Comparison of mouse effective dose 80% (ED80) or curative dose 80% (CD80) values with cattle minimum curative dose (MCD) values demonstrated a wide variation between trypanosome strains. Although a mouse test may give a broad indication of the sensitivity of a strain, it cannot be used to predict curative doses for cattle. It was concluded that care should be exercised in extrapolating the results of a mouse test to cattle.
在小鼠和牛身上测定了3株刚果锥虫对氯化异美汀（Samorin）的敏感性，目的是评估小鼠敏感性试验作为预测牛治疗剂量的一种方法。将小鼠80%有效剂量（ED80）或80%治疗剂量（CD80）值与牛最低治疗剂量（MCD）值进行比较，结果表明锥虫菌株之间存在很大差异。虽然小鼠试验可以大致表明菌株的敏感性，但不能用于预测牛的治疗剂量。得出的结论是，在将小鼠试验结果外推至牛时应谨慎行事。
