Shulman D I, Strzelecki J A, Bercu B B, Root A W
Department of Pediatrics, University of South Florida College of Medicine, Tampa.
Am J Dis Child. 1988 Sep;142(9):972-4. doi: 10.1001/archpedi.1988.02150090070025.
Transplacental passage of thyrotropin (TSH)-binding inhibitory immunoglobulins may result in transient congenital hypothyroidism. We measured serum TSH-binding inhibitory index (TBII) in 11 infants with abnormal screening findings using a commercially available kit. Two of the infants, who were siblings, had markedly elevated TBII values (90% and 100%, respectively), as did their mother (89%, 100%), and had a clinical course consistent with transient antibody-mediated hypothyroidism. Four other infants had a borderline or mildly elevated TBII that was not present in maternal serum, suggesting that endogenous TSH was being measured in this assay. The TBII was measured in the sera of 18 additional children with primary hypothyroidism and in human TSH standards from 25 to 2000 mU/L. Increasing concentrations of TSH were associated with a linear increase in TBII. Measurement of TBII by this method may identify infants with transient antibody-mediated hypothyroidism, although simultaneous assessment of maternal serum is necessary.
促甲状腺激素（TSH）结合抑制性免疫球蛋白的经胎盘传递可能导致暂时性先天性甲状腺功能减退。我们使用市售试剂盒对11名筛查结果异常的婴儿进行了血清TSH结合抑制指数（TBII）测定。其中两名婴儿是 siblings，其TBII值显著升高（分别为90%和100%），他们的母亲也是如此（89%，100%），且临床病程符合暂时性抗体介导的甲状腺功能减退。另外四名婴儿的TBII处于临界值或轻度升高，而其母亲血清中未出现这种情况，这表明该检测方法检测到的是内源性TSH。我们还对另外18名原发性甲状腺功能减退儿童的血清以及浓度为25至2000 mU/L的人TSH标准品进行了TBII测定。TSH浓度的增加与TBII呈线性增加相关。通过这种方法测定TBII可能识别出暂时性抗体介导的甲状腺功能减退婴儿，不过同时评估母亲血清是必要的。
