Iseki M, Shimizu M, Oikawa T, Hojo H, Arikawa K, Ichikawa Y, Momotani N, Ito K
J Clin Endocrinol Metab. 1983 Aug;57(2):384-7. doi: 10.1210/jcem-57-2-384.
Infants with transient neonatal hypothyroidism, in whom TSH binding inhibitor immunoglobulin G (IgG) (TBII) were sequentially measured, are described. Their mother had been taking thyroid replacement for hypothyroidism due to nongoitrous autoimmune thyroiditis. IgGs inhibiting TSH binding were detected in maternal sera by radioreceptor assay. These IgGs also inhibited the adenylate cyclase response to TSH in human thyroid membranes. Three infants had frank hypothyroidism immediately after birth, and TBII were detected in two of them. In the two surviving infants, hypothyroidism was transient and improved when TBII disappeared from their sera. The profile of TBII in one patient corresponded to the IgG disappearance curve. These findings suggest that the transient neonatal hypothyroidism reported was caused by transplacental transfer of TBII.
本文描述了对患有短暂性新生儿甲状腺功能减退症的婴儿进行促甲状腺激素结合抑制免疫球蛋白G（IgG）（TBII）的连续测量情况。这些婴儿的母亲因非甲状腺肿性自身免疫性甲状腺炎导致甲状腺功能减退而接受甲状腺替代治疗。通过放射受体分析法在母体血清中检测到抑制促甲状腺激素结合的IgG。这些IgG也抑制人甲状腺膜中促甲状腺激素对腺苷酸环化酶的反应。三名婴儿出生后立即出现明显的甲状腺功能减退，其中两名检测到TBII。在两名存活的婴儿中，甲状腺功能减退是短暂的，当血清中TBII消失时病情改善。一名患者的TBII情况与IgG消失曲线相符。这些发现表明，所报道的短暂性新生儿甲状腺功能减退症是由TBII经胎盘转移引起的。
