Roine R P, Turpeinen U, Ylikahri R, Salaspuro M
Research Unit of Alcohol Disease, Meilahti Hospital Laboratory, Helsinki University Central Hospital, Finland.
Alcohol Clin Exp Res. 1987 Dec;11(6):525-7. doi: 10.1111/j.1530-0277.1987.tb00166.x.
Urinary dolichol levels of 31 skid-row alcoholics and 49 alcoholics entering a detoxification unit were compared to those of 51 nonalcoholic controls (social drinkers). The mean urinary dolichol content as related to urinary creatinine was significantly (p less than 0.001) higher in the two groups of alcoholics than in the controls. In this material the sensitivity of increased urinary dolichol in the detection of alcoholism was 68% as compared to 44% sensitivity of serum gamma-glutamyltransferase. The percentage of false-positives in the control group was 3.9%. Urinary dolichol is suggested as a potential tool for the detection and follow-up of alcohol abuse.
将31名贫民窟酗酒者和49名进入戒毒所的酗酒者的尿中多萜醇水平与51名非酗酒对照者（社交饮酒者）的进行了比较。两组酗酒者尿中多萜醇与尿肌酐相关的平均含量显著高于对照组（p小于0.001）。在该样本中，尿中多萜醇升高在检测酗酒方面的敏感性为68%，而血清γ-谷氨酰转移酶的敏感性为44%。对照组中的假阳性率为3.9%。尿中多萜醇被认为是检测和跟踪酒精滥用的一种潜在工具。
