甘氨酸可逆转1-羟基-3-氨基吡咯烷-2（HA-966）对大鼠皮层切片中N-甲基-D-天冬氨酸（NMDA）的拮抗作用，但不能逆转D-2-氨基-5-磷酸戊酸（D-AP5）对其的拮抗作用。 - Suppr

Suppr

超能文献

Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices.

作者信息

Fletcher E J, Lodge D

机构信息

Department of Basic Sciences, Royal Veterinary College, London, U.K.

出版信息

Eur J Pharmacol. 1988 Jun 22;151(1):161-2. doi: 10.1016/0014-2999(88)90711-x.

DOI:10.1016/0014-2999(88)90711-x

PMID:2901361

Abstract

摘要

相似文献

Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices.甘氨酸可逆转1-羟基-3-氨基吡咯烷-2（HA-966）对大鼠皮层切片中N-甲基-D-天冬氨酸（NMDA）的拮抗作用，但不能逆转D-2-氨基-5-磷酸戊酸（D-AP5）对其的拮抗作用。

Eur J Pharmacol. 1988 Jun 22;151(1):161-2. doi: 10.1016/0014-2999(88)90711-x.

Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina.甘氨酸可逆转HA - 966对培养的大鼠皮层神经元和鸡视网膜中NMDA反应的作用。

Neurosci Lett. 1989 Apr 10;98(3):333-8. doi: 10.1016/0304-3940(89)90424-2.

Glycine potentiates NMDA responses in rat hippocampal CA1 neurons.甘氨酸可增强大鼠海马CA1神经元中的NMDA反应。

Neurosci Lett. 1989 May 22;100(1-3):237-42. doi: 10.1016/0304-3940(89)90691-5.

Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus.N-甲基-D-天冬氨酸受体的激活会诱导海马中血影蛋白的蛋白水解。

Brain Res. 1988 Sep 13;460(1):189-94. doi: 10.1016/0006-8993(88)91222-x.

Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.HA-966（1-羟基-3-氨基吡咯烷-2）的（R）-对映体在N-甲基-D-天冬氨酸受体复合物甘氨酸位点的立体选择性。

J Neurochem. 1990 Oct;55(4):1346-51. doi: 10.1111/j.1471-4159.1990.tb03145.x.

HA-966 acts at a modulatory glycine site to inhibit N-methyl-D-aspartate-evoked neurotransmitter release.HA - 966作用于一个调节性甘氨酸位点，以抑制N - 甲基 - D - 天冬氨酸诱发的神经递质释放。

Eur J Pharmacol. 1989 Aug 3;166(3):393-400. doi: 10.1016/0014-2999(89)90351-8.

Ca2+-dependent depolarization and burst firing of rat CA1 pyramidal neurones induced by N-methyl-D-aspartic acid and quinolinic acid: antagonism by 2-amino-5-phosphonovaleric and kynurenic acids.

Can J Physiol Pharmacol. 1986 Feb;64(2):163-8. doi: 10.1139/y86-024.

Ethanol inhibits N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat cortical slices.乙醇抑制N-甲基-D-天冬氨酸刺激的大鼠皮层切片中[3H]去甲肾上腺素的释放。

J Pharmacol Exp Ther. 1990 Jun;253(3):1138-44.

Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices.右啡烷和右美沙芬是常见的止咳药，它们具有抗癫痫作用，并能在脑片中拮抗N-甲基-D-天冬氨酸。

Neurosci Lett. 1988 Feb 29;85(2):261-6. doi: 10.1016/0304-3940(88)90362-x.

EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs.体外培养的大鼠新皮质神经元中的兴奋性突触后电位。II. N-甲基-D-天冬氨酸受体在兴奋性突触后电位产生中的作用。

J Neurophysiol. 1989 Mar;61(3):621-34. doi: 10.1152/jn.1989.61.3.621.

引用本文的文献

The 1980s: D-AP5, LTP and a Decade of NMDA Receptor Discoveries.20 世纪 80 年代：D-AP5、LTP 和十年的 NMDA 受体发现。

Neurochem Res. 2019 Mar;44(3):516-530. doi: 10.1007/s11064-018-2640-6. Epub 2018 Oct 4.

The NMDA receptor as a target for cognitive enhancement.NMDA 受体作为认知增强的靶点。

Neuropharmacology. 2013 Jan;64:13-26. doi: 10.1016/j.neuropharm.2012.06.051. Epub 2012 Jul 11.

D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons.D-丝氨酸对大鼠海马CA1区锥体细胞和中间神经元中NMDA受体功能的调节作用不同。

J Physiol. 2003 Apr 15;548(Pt 2):411-23. doi: 10.1113/jphysiol.2002.037127. Epub 2003 Feb 28.

E-p-methoxycinnamic acid protects cultured neuronal cells against neurotoxicity induced by glutamate.对甲氧基肉桂酸乙酯可保护培养的神经元细胞免受谷氨酸诱导的神经毒性。

Br J Pharmacol. 2002 Mar;135(5):1281-91. doi: 10.1038/sj.bjp.0704576.

The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain.甘氨酸B结合位点和甘氨酸转运体（GlyT1）在调节大鼠脑内[3H]GABA和[3H]甘氨酸释放中的作用。

Neurochem Res. 2001 Sep;26(8-9):915-23. doi: 10.1023/a:1012328300037.

Modulation of N-methyl-D-aspartate receptor function by glycine transport.通过甘氨酸转运对N-甲基-D-天冬氨酸受体功能的调节

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15730-4. doi: 10.1073/pnas.95.26.15730.

Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.NMDA受体甘氨酸亲和力和ifenprodil敏感性的发育变化揭示了单个大鼠皮层神经元中三种不同类型的NMDA受体。

J Neurosci. 1998 Mar 15;18(6):1935-43. doi: 10.1523/JNEUROSCI.18-06-01935.1998.

Comparison of the effects of NMDA and AMPA antagonists on the locomotor activity induced by selective D1 and D2 dopamine agonists in reserpine-treated mice.NMDA和AMPA拮抗剂对利血平处理小鼠中选择性D1和D2多巴胺激动剂诱导的运动活性的影响比较。

Psychopharmacology (Berl). 1994 Apr;114(3):469-76. doi: 10.1007/BF02249338.

Comparative anterograde amnestic and anticonvulsant effects of two types of NMDA receptor antagonists: MK-801 and HA-966.

Psychopharmacology (Berl). 1995 Feb;117(3):333-9. doi: 10.1007/BF02246108.

Competitive and uncompetitive N-methyl-D-aspartate antagonist discriminations in pigeons: CGS 19755 and phencyclidine.

Psychopharmacology (Berl). 1995 Mar;118(1):42-51. doi: 10.1007/BF02245248.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验