神经活性物质的释放：同型半胱氨酸作为N-甲基-D-天冬氨酸受体的内源性激动剂。
Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor.
作者信息
Do K Q, Herrling P L, Streit P, Cuénod M
机构信息
Brain Research Institute, University of Zürich, Switzerland.
出版信息
J Neural Transm. 1988;72(3):185-90. doi: 10.1007/BF01243418.
Sulfur containing amino acids such as homocysteic acid (HCA), cysteinsulfinic acid, homocysteinsulfinic acid are released by depolarization of slices from various rat brain regions in a Ca++-dependent manner. L-HCA excites caudate neurons through their N-methyl-D-aspartic acid (NMDA) receptor and potentiates their cortically evoked excitatory postsynaptic potentials. 35S-methionine can label the releasable pool of HCA, and thus appears as a precursor of HCA. Thus HCA is a transmitter candidate which acts predominantly on the NMDA receptor.
含硫氨基酸，如高半胱氨酸（HCA）、半胱亚磺酸、高半胱亚磺酸，以钙离子依赖的方式从大鼠不同脑区的切片去极化中释放出来。L-HCA通过其N-甲基-D-天冬氨酸（NMDA）受体兴奋尾状核神经元，并增强其皮层诱发的兴奋性突触后电位。35S-甲硫氨酸可以标记HCA的可释放池，因此似乎是HCA的前体。因此，HCA是一种主要作用于NMDA受体的候选神经递质。
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