Gilbert R J, Ingram G S
Gibbs Dental Division, Unilever Research, Merseyside, UK.
J Pharm Pharmacol. 1988 Jun;40(6):399-402. doi: 10.1111/j.2042-7158.1988.tb06303.x.
Zinc is retained in the mouth after use of a toothpaste containing 0.5% zinc citrate. More than one third of the dose was found to be retained after normal brushing. Elevated zinc levels were also found in plaque. Saliva zinc levels were significantly above background for at least 2 h after brushing. In-vitro experiments demonstrated that zinc can bind to the pellicle-coated tooth surface and can subsequently adsorb into saliva. Plaque can calcify to form calculus containing appreciable levels of hydroxyapatite. Zinc adsorbs to hydroxyapatite inhibiting crystal growth. Levels of zinc in plaque were found to be considerably higher than those taken up by hydroxyapatite in an in-vitro test of crystal growth inhibition indicating the potential of zinc to inhibit calculus formation.
使用含0.5%柠檬酸锌的牙膏后，锌会留存于口腔中。正常刷牙后，发现超过三分之一的剂量会留存下来。在牙菌斑中也发现锌含量升高。刷牙后至少2小时内，唾液中的锌水平显著高于基线水平。体外实验表明，锌可与覆盖有获得性膜的牙齿表面结合，随后吸附到唾液中。牙菌斑可钙化形成含有相当水平羟基磷灰石的牙结石。锌吸附到羟基磷灰石上会抑制晶体生长。在体外晶体生长抑制试验中，发现牙菌斑中的锌水平远高于羟基磷灰石所吸收的锌水平，这表明锌具有抑制牙结石形成的潜力。
