1 Center for Gut Rehabilitation and Transplantation Clinician, Cleveland Clinic, Cleveland, Ohio, USA.
2 Home Nutrition Support Clinician, Cleveland Clinic, Cleveland, Ohio, USA.
Nutr Clin Pract. 2017 Dec;32(6):753-768. doi: 10.1177/0884533617735089. Epub 2017 Oct 10.
Home parenteral nutrition (HPN) has benefited countless patients since its initiation almost 5 decades ago. Over time, HPN has been found to be associated with various complications, including metabolic disorders. Metabolic complications can be grouped into short-term (eg, fluid imbalance, electrolyte disturbances, glucose abnormalities) and long-term (eg, hepatobiliary disorders, metabolic bone disease, iron deficiency anemia, manganese toxicity) categories. There are a number of treatment options for each complication. It is important to evaluate the entire clinical picture prior to initiating an intervention and use evidence-based interventions when available. A dedicated multidisciplinary team is best suited to prevent and manage complications when they are identified.
家庭肠外营养（HPN）自近 50 年前开始以来，为数以千计的患者带来了益处。随着时间的推移，人们发现 HPN 与各种并发症有关，包括代谢紊乱。代谢并发症可分为短期（例如，液体失衡、电解质紊乱、葡萄糖异常）和长期（例如，肝胆疾病、代谢性骨病、缺铁性贫血、锰中毒）两类。对于每种并发症，都有多种治疗选择。在开始干预之前，评估整个临床情况并在有证据时使用基于证据的干预措施非常重要。当发现并发症时，专门的多学科团队最适合预防和管理并发症。
