长脉冲钕：钇铝石榴石激光治疗甲银屑病
Long-Pulsed Nd: YAG Laser Treatment for Nail Psoriasis.
作者信息
Kartal Selda Pelin, Canpolat Filiz, Gonul Muzeyyen, Ergin Can, Gencturk Zeynep
机构信息
Department of Dermatology, University of Health Sciences, DiskapıYildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Faculty of Medicine Biostatistics, Ankara University, Ankara, Turkey.
出版信息
Dermatol Surg. 2018 Feb;44(2):227-233. doi: 10.1097/DSS.0000000000001294.
BACKGROUND
Psoriasis is a chronic inflammatory skin disease in which lesions display angiogenesis and increased vascularity.
OBJECTIVE
The long-pulsed 1,064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser treats vascular lesions which suggests that it might also be used to treat nail psoriasis.
METHODS
Sixteen patients (10 males and 6 females) with isolated nail psoriasis or nail with only mild cutaneous involvement were enrolled in the study. Nails were treated for 3 sessions with long-pulsed 1,064-nm Nd:YAG laser once monthly. During the course of the treatment, nail bed and matrix Nail Psoriasis Severity Index (NAPSI) scores were recorded.
RESULTS
The mean baseline NAPSI score was 26 ± 7.2. The means of total NAPSI scores after the first, second, and third treatment sessions were as follows: 22 ± 6.6, 13 ± 6, and 5.7 ± 4.3, respectively. The decline in NAPSI score was statistically significant. At the end of the 3 treatment sessions, both nail bed and matrix lesions significantly responded to Nd:YAG laser treatment.
CONCLUSION
The Nd:YAG laser is a promising treatment option for nail psoriasis.
背景
银屑病是一种慢性炎症性皮肤病，其皮损表现为血管生成增加和血管增多。
目的
长脉冲1064纳米钕：钇铝石榴石（Nd:YAG）激光可治疗血管性病变，这表明它也可能用于治疗甲银屑病。
方法
16例孤立性甲银屑病或仅伴有轻度皮肤受累的甲病患者纳入本研究。使用长脉冲1064纳米Nd:YAG激光对指甲进行3次治疗，每月1次。在治疗过程中，记录甲床和甲母质的甲银屑病严重程度指数（NAPSI）评分。
结果
NAPSI评分的平均基线值为26±7.2。第一次、第二次和第三次治疗后NAPSI总分的平均值分别为：22±6.6、13±6和5.7±4.3。NAPSI评分的下降具有统计学意义。在3次治疗结束时，甲床和甲母质病变对Nd:YAG激光治疗均有显著反应。
结论
Nd:YAG激光是治疗甲银屑病的一种有前景的治疗选择。
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