Sone Daichi, Ikegaya Naoki, Takahashi Akio, Sumida Kaoru, Ota Miho, Saito Takashi, Kimura Yukio, Matsuda Hiroshi, Sato Noriko
Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan; Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8654, Japan.
Department of Neurosurgery, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
Epilepsy Res. 2017 Dec;138:1-4. doi: 10.1016/j.eplepsyres.2017.10.001. Epub 2017 Oct 6.
Recent studies using rat models suggested that epileptic discharges (EDs) can induce focal brain hyperthermia, but such ED-related hyperthermia has not been confirmed in humans. We examined hyperthermia of the focus of epilepsy using noninvasive proton magnetic resonance spectroscopy (H-MRS) thermometry. We recruited six pediatric patients with refractory daily seizures, continuous interictal epileptic discharges, and concordant focus lesions on MRI who had undergone comprehensive presurgical exams. H-MRS thermometry calculated the temperatures of the presumed epileptogenic lesions, and we examined the contralateral counterparts in each patient as controls. As a result, the mean temperature of the epileptogenic foci (36.81°C) was significantly higher than that of the controls (36.01°C). The mean difference was 0.81°C (95%CI: 0.22-1.39, p=0.017). H-MRS thermometry may have the ability to noninvasively detect focal brain hyperthermia related to continuous EDs in human subjects, and to contribute to a better understanding and focus detection of epilepsy.
最近使用大鼠模型的研究表明，癫痫放电（EDs）可诱发局灶性脑热，但这种与ED相关的热在人类中尚未得到证实。我们使用无创质子磁共振波谱（H-MRS）测温法检查了癫痫病灶的热情况。我们招募了6名患有难治性每日发作、持续性发作间期癫痫放电且MRI上有一致病灶的儿科患者，这些患者均接受了全面的术前检查。H-MRS测温法计算了假定的致痫病灶的温度，并将每位患者的对侧对应部位作为对照进行检查。结果，致痫灶的平均温度（36.81°C）显著高于对照组（36.01°C）。平均差值为0.81°C（95%CI：0.22-1.39，p=0.017）。H-MRS测温法可能有能力在人类受试者中无创检测与持续性ED相关的局灶性脑热，并有助于更好地理解和检测癫痫病灶。
