Kuo A H, Li J, Li C, Huber H F, Nathanielsz P W, Clarke G D
1Department of Radiology and Research Imaging Institute,University of Texas Health Science Center at San Antonio,San Antonio,TX,USA.
2Xiangya School of Medicine,Central South University,Changsha,Hunan,China.
J Dev Orig Health Dis. 2018 Apr;9(2):137-142. doi: 10.1017/S2040174417000770. Epub 2017 Oct 11.
The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P<0.005) and AD (1.7±0.2 v. 4.0±0.5×10-3/mmHg, P<0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. Future studies should evaluate potential consequences of these changes on coronary perfusion, afterload and blood pressure.
主动脉缓冲血流并提供舒张期灌注的能力（Windkessel功能）是心血管健康的一个决定因素。我们曾报道，由于母亲孕期适度营养减少，出生时为子宫内生长受限（IUGR）的年轻成年狒狒存在提示下游血管异常的心脏功能障碍。我们使用3T磁共振成像（MRI）检查了IUGR后代（8只雄性，8只雌性；5.7岁；相当于人类25岁）和年龄匹配的对照组（8只雄性，8只雌性；5.6岁），以量化降主动脉远端的横截面积（AC）和扩张性（AD）。方差分析显示，IUGR组的AC/体表面积降低（0.9±0.05cm²/m²对1.2±0.06cm²/m²，均数±标准误，P<0.005），AD降低（1.7±0.2对4.0±0.5×10⁻³/mmHg，P<0.005），且无性别差异或组间-性别交互作用，提示存在内在血管病变且发育受损持续至成年期。未来的研究应评估这些变化对冠状动脉灌注、后负荷和血压的潜在影响。
