Li Cun, Jenkins Susan, Huber Hillary F, Nathanielsz Peter W
Department of Animal Sciences, Texas Pregnancy and Life-course Health Center, University of Wyoming, Laramie, Wyoming.
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.
J Med Primatol. 2019 Aug;48(4):226-235. doi: 10.1111/jmp.12415. Epub 2019 Apr 26.
Non-human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months.
Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high-fat high-energy diet through lactation.
Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0-3 years, catch-up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups.
Mismatch produces sexually dimorphic post-natal growth phenotypes.
需要通过孕期和哺乳期饮食不匹配的母体发育编程的非人灵长类动物模型来转化为人类编程结果。我们展示了狒狒后代从出生到3岁的形态测量数据，以及2至24个月时的血液皮质醇和促肾上腺皮质激素（ACTH）数据。
对照母亲食用普通食物；不匹配组母亲在孕期进食量比对照组少30%，并在哺乳期食用高脂高能量饮食。
不匹配组母亲在孕期体重减轻。出生时，两性不匹配组后代体重均有降低趋势（P = 0.06）。从0至3岁，出现追赶生长。不匹配组后代的雄性和雌性体重增长均快于对照组（P < 0.001）。与对照组相比，不匹配组雌性后代的BMI（P < 0.001）和腹围（P = 0.008）增加幅度更大。两组两性在2至24个月龄时的ACTH和皮质醇斜率相似。所有组在断奶后皮质醇和ACTH均升高。
不匹配会产生两性产后生长表型差异。
