2015 - 2016年季节性流感疫苗对实验室确诊流感的有效性：立陶宛一项基于医院的检测阴性病例对照研究
Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015-2016: a hospital-based test-negative casecontrol study in Lithuania.
作者信息
Kuliese Monika, Jancoriene Ligita, Grimalauskaite Rita, Zablockiene Birute, Damuleviciene Gyte, Velyvyte Daiva, Lesauskaite Vita, Ambrozaitis Arvydas, Mickiene Aukse, Gefenaite Giedre
机构信息
Department of Infectious Diseases, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Clinic of Infectious, Chest Diseases, Dermatovenerology and Allergology, Vilnius University Faculty of Medicine, Vilnius, Lithuania.
出版信息
BMJ Open. 2017 Oct 10;7(10):e017835. doi: 10.1136/bmjopen-2017-017835.
OBJECTIVE
A case-control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015-2016 influenza season.
METHODS
A study was performed in three departments in Lithuania between 1 December 2015 and 1 May 2016. Data on demographic and clinical characteristics including influenza vaccination status were collected from the patients recommended to receive the seasonal influenza vaccine. Influenza virus infection was confirmed by multiplex reverse transcription polymerase chain reaction (RT-PCR) .
RESULTS
Ninety-one (56.4%) of the 163 included subjects were ≥65 years old. Fifteen (9.2%) subjects were vaccinated against influenza at least 2 weeks before the onset of influenza symptoms, 12 of them were ≥65 years old. Of the 72 (44.2%) influenza virus positive cases, 65 (39.9%) were confirmed with influenza A (including 50 cases of influenza A(H1N1)pdm09), eight (4.9%) were confirmed with influenza B and one was a co-infection. Unadjusted SIVE against any influenza, influenza type A and influenza A(H1N1)pdm09 was 57% (95% CI -41% to 87%), 52% (95% CI -57% to 85%) and 70% (95% CI -43% to 94%) respectively.
CONCLUSION
Although SIVE estimates were not statistically significant the point estimates suggest moderate effectiveness against influenza type A.
目的
开展一项病例对照研究，以评估2015 - 2016年流感季节的季节性流感疫苗效力（SIVE）。
方法
2015年12月1日至2016年5月1日期间在立陶宛的三个科室进行了一项研究。从被推荐接种季节性流感疫苗的患者中收集包括流感疫苗接种状况在内的人口统计学和临床特征数据。通过多重逆转录聚合酶链反应（RT-PCR）确认流感病毒感染。
结果
163名纳入研究的对象中，91名（56.4%）年龄≥65岁。15名（9.2%）对象在出现流感症状前至少2周接种了流感疫苗，其中12名年龄≥65岁。在72例（44.2%）流感病毒阳性病例中，65例（39.9%）确诊为甲型流感（包括50例甲型（H1N1）pdm09流感），8例（4.9%）确诊为乙型流感，1例为混合感染。针对任何流感、甲型流感和甲型（H1N1）pdm09流感的未调整SIVE分别为57%（95%CI -41%至87%）、52%（95%CI -57%至85%）和70%（95%CI -43%至94%）。
结论
尽管SIVE估计值无统计学意义，但点估计值表明对甲型流感有中等效力。
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