Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae.
作者信息
Watanabe Yoshihiro, Asami Yukihiro, Narusawa Satomi, Hashimoto Shohei, Iwatsuki Masato, Nonaka Kenichi, Shinohara Yasuo, Shiotsuki Takahiro, Ichimaru Naoya, Miyoshi Hideto, Ōmura Satoshi, Shiomi Kazuro
机构信息
Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 2017 Oct 11. doi: 10.1038/ja.2017.118.
A new lanostane-type triterpenoid, ascosteroside D, was isolated from a fungus, Aspergillus sp. FKI-6682. It inhibited insect ADP/ATP carrier protein (AAC)-expressing Saccharomyces cerevisiae in glycerol-containing medium, but did not inhibit Δaac S. cerevisiae in glucose-containing medium. It is hypothesized that ascosteroside D inhibits ATP production in mitochondria.The Journal of Antibiotics advance online publication, 11 October 2017; doi:10.1038/ja.2017.118.
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