癸聚异戊二烯酸，一种通过使用对药物敏感的酿酒酵母进行农药筛选而发现的新型线粒体呼吸抑制剂。
Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae.
作者信息
Watanabe Yoshihiro, Suga Takuya, Narusawa Satomi, Iwatsuki Masato, Nonaka Kenichi, Nakashima Takuji, Shinohara Yasuo, Shiotsuki Takahiro, Ichimaru Naoya, Miyoshi Hideto, Asami Yukihiro, Ōmura Satoshi, Shiomi Kazuro
机构信息
Department of Drug Discovery Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 2017 Apr;70(4):395-399. doi: 10.1038/ja.2016.164. Epub 2017 Jan 18.
A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.
从酱油曲霉FKI-6817的培养液中分离出一种新的萘烷——十氢萘甲酸。通过核磁共振（NMR）和电子圆二色光谱（ECD）确定了其绝对构型。十氢萘甲酸（10 μM）对从野生型酿酒酵母中分离出的线粒体ATP生成有~50%的抑制作用，而不影响呼吸酶的活性。作为一种新型农药的潜在种子，该化合物的作用方式可能很有趣。
Zotero 插件