Ben Younès-Chennoufi A, Said G, Eisen H, Durand A, Hontebeyrie-Joskowicz M
Faculté de Médecine Paris XI, Le Kremlin-Bicêtre, France.
Trans R Soc Trop Med Hyg. 1988;82(1):84-9. doi: 10.1016/0035-9203(88)90271-4.
The infection of mice with Trypanosoma cruzi has been used as an experimental model for human Chagas disease, because the murine and human infections have similar acute and chronic phases generating similar immunopathological phenomena. Histopathological studies of murine tissues showed that the inflammatory lesions were small during the acute phase and composed mainly of mononuclear cells. During the chronic phase, cellular infiltrates were clustered in large granulomata consisting of mononuclear and polynuclear neutrophil cells. Characterization of the infiltrating cells by surface markers showed that about 6% were Thyl.2+ T cells, and CD4+(Lyt 1+) T cells (T helper/DTH subset) were more numerous than CD8+(Lyt 2+) T cells. These observations suggest that delayed type hypersensitivity plays a role in the pathology of Chagas disease.
用克氏锥虫感染小鼠已被用作人类恰加斯病的实验模型，因为鼠类和人类感染具有相似的急性和慢性阶段，会产生相似的免疫病理现象。对鼠类组织的组织病理学研究表明，急性期炎症病变较小，主要由单核细胞组成。在慢性期，细胞浸润聚集形成由单核和多形核中性粒细胞组成的大肉芽肿。通过表面标志物对浸润细胞进行表征显示，约6%为Thyl.2+ T细胞，且CD4+(Lyt 1+) T细胞（辅助性T细胞/迟发型超敏反应亚群）比CD8+(Lyt 2+) T细胞数量更多。这些观察结果表明，迟发型超敏反应在恰加斯病的病理过程中起作用。
