Chang Kuei-Jung, Cheng Cheng-Kuo, Peng Chi-Hsien
Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
School of Medicine, Catholic Fu-Jen University, New Taipei City, Taiwan.
Taiwan J Ophthalmol. 2016 Jul-Sep;6(3):136-140. doi: 10.1016/j.tjo.2016.05.007. Epub 2016 Jun 24.
BACKGROUND/PURPOSE: This study aims to evaluate the clinical characteristics and visual outcome of macular hemorrhage in pathological myopia with or without choroidal neovascularization.
We conducted a retrospective study of 55 patients with macular coin hemorrhage who were followed for at least 3 months from January 1997 to December 2013 at Shin Kong Wu Ho-Su Memorial Hospital (Taipei, Taiwan). All patients were evaluated using fluorescein angiography and optical coherence tomography for the detection of choroidal neovascularization (CNV). We also recorded clinical characteristics such as age, sex, refractory error, and myopic fundus, to determine the relationship between CNV and non-CNV associated macular hemorrhage.
A total of 55 patients (30 females, 54.55%) were reviewed. The mean age was 39.7 years old. The CNV group was found to be significantly older than the non-CNV group ( < 0.05), and there was no significant difference between sex, visual acuity myopic severity, and the prevalence of fundus findings between CNV and non-CNV groups. Twenty one patients (38.18%) were found to have CNV and were all treated with intravitreal antivascular endothelial growth factor (VEGF). The other 34 patients without CNV were not treated. In both groups, the visual acuity significantly improved (anti-VEGF treated, CNV associated group, 0.7 to 0.39, = 0.002, and untreated, non-CNV associated group, 0.56 to 0.34, = 0.0018, respectively).
Age significantly correlated to the CNV formation in high myopia with macular hemorrhage. Favorable visual outcomes were found in pathological myopic macular hemorrhage either in the anti-VEGF treated, CNV associated group or in the untreated, non-CNV associated group.
背景/目的：本研究旨在评估伴有或不伴有脉络膜新生血管的病理性近视性黄斑出血的临床特征及视力预后。
我们对1997年1月至2013年12月在台北市新光吴火狮纪念医院随访至少3个月的55例黄斑区钱币状出血患者进行了一项回顾性研究。所有患者均接受荧光素血管造影和光学相干断层扫描以检测脉络膜新生血管（CNV）。我们还记录了年龄、性别、屈光不正和近视眼底等临床特征，以确定CNV与非CNV相关黄斑出血之间的关系。
共纳入55例患者（30例女性，占54.55%）。平均年龄为39.7岁。发现CNV组的年龄显著大于非CNV组（P<0.05），CNV组和非CNV组在性别、视力近视严重程度和眼底表现患病率方面无显著差异。21例患者（38.18%）被发现有CNV，均接受玻璃体内抗血管内皮生长因子（VEGF）治疗。另外34例无CNV的患者未接受治疗。两组患者的视力均显著提高（抗VEGF治疗的CNV相关组，从0.7提高到0.39，P=0.002；未治疗的非CNV相关组，从0.56提高到0.34，P=0.0018）。
年龄与高度近视性黄斑出血的CNV形成显著相关。在接受抗VEGF治疗的CNV相关组或未治疗的非CNV相关组中，病理性近视性黄斑出血均有良好的视力预后。
