Wirth M D, Shivappa N, Davis L, Hurley T G, Ortaglia A, Drayton R, Blair S N, Hébert J R
Michael Wirth, MSPH, PhD, Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, University of South Carolina, 915 Greene Street, Room 233, Columbia, SC 29208. Phone: (803) 576-5646. Fax: (803) 576-5624. Email:
J Nutr Health Aging. 2017;21(5):487-491. doi: 10.1007/s12603-016-0775-1.
Chronic inflammation is linked to many chronic conditions. One of the strongest modulators of chronic inflammation is diet. The Dietary Inflammatory Index (DII) measures dietary inflammatory potential and has been validated previously, but not among African Americans (AAs).
Cross-sectional analysis using baseline data from the Healthy Eating and Active Living in the Spirit (HEALS) intervention study.
Baseline data collection occurred between 2009 and 2012 in or near Columbia, SC.
African-American churchgoers.
Baseline data collection included c-reactive protein (CRP) and interleukin-6 from blood draws, anthropometric measures, and numerous questionnaires. The questionnaires included a food frequency questionnaire which was used for DII calculation. The main analyses were performed using quantile regression.
Subjects in the highest DII quartile (i.e., more pro-inflammatory) were younger, more likely to be married, and had less education and greater BMI. Individuals in DII quartile 4 had statistically significantly greater CRP at the 75th and 90th percentiles of CRP versus those in quartile 1 (i.e., more anti-inflammatory).
Construct validation provides support for using the DII in research among AA populations. Future research should explore avenues to promote more anti-inflammatory diets, with use of the DII, among AA populations to reduce risk of chronic disease.
慢性炎症与许多慢性疾病相关。饮食是慢性炎症最强的调节因素之一。饮食炎症指数（DII）可衡量饮食的炎症潜力，此前已得到验证，但在非裔美国人（AA）中尚未验证。
使用“精神层面的健康饮食与积极生活”（HEALS）干预研究的基线数据进行横断面分析。
2009年至2012年期间在南卡罗来纳州哥伦比亚市或其附近进行基线数据收集。
非裔美国教会成员。
基线数据收集包括血液中C反应蛋白（CRP）和白细胞介素-6、人体测量指标以及大量问卷。问卷包括用于计算DII的食物频率问卷。主要分析采用分位数回归。
DII四分位数最高组（即促炎作用更强）的受试者更年轻，更可能已婚，受教育程度较低且体重指数更高。与四分位数第1组（即抗炎作用更强）相比，DII四分位数第4组的个体在CRP的第75和第90百分位数处的CRP在统计学上显著更高。
结构效度验证为在非裔美国人群体的研究中使用DII提供了支持。未来的研究应探索利用DII在非裔美国人群体中推广更多抗炎饮食的途径，以降低慢性病风险。
