Veronese Nicola, Stubbs Brendon, Solmi Marco, Noale Marianna, Vaona Alberto, Demurtas Jacopo, Maggi Stefania
1National Research Council, Neuroscience Institute,Aging Branch,35128, Padova,Italy.
3Physiotherapy Department,South London and Maudsley NHS Foundation Trust,Denmark Hill,London SE5 8AZ,UK.
Br J Nutr. 2017 Jun;117(11):1570-1576. doi: 10.1017/S0007114517001350. Epub 2017 Jun 20.
Research considering the relationship between dietary Mg and osteoporosis as well as fractures are sparse and conflicting. We therefore aimed to investigate Mg intake and the onset of fractures in a large cohort of American men and women involved in the Osteoarthritis Initiative over a follow-up period of 8 years. Dietary Mg intake (including that derived from supplementation) was evaluated through a FFQ at baseline and categorised using sex-specific quintiles (Q); osteoporotic fractures were evaluated through self-reported history. Overall, 3765 participants (1577 men; 2071 women) with a mean age of 60·6 (sd 9·1) years were included. During follow-up, 560 individuals (198 men and 368 women) developed a new fracture. After adjusting for fourteen potential confounders at baseline and taking those with lower Mg intake as reference (Q1), men (hazard ratio (HR) 0·47; 95 % CI 0·21, 1·00, P=0·05) and women (HR 0·38; 95 % CI 0·17, 0·82, P=0·01) in the highest quintile reported a significantly lower risk for fracture. Women meeting the recommended Mg intake were at a 27 % decreased risk for future fractures. In conclusion, higher dietary Mg intake has a protective effect on future osteoporotic fractures, especially in women with a high risk for knee osteoarthritis. Those women meeting the recommended Mg intake appear to be at a lower risk for fractures.
关于饮食中镁与骨质疏松症以及骨折之间关系的研究稀少且相互矛盾。因此，我们旨在调查参与骨关节炎倡议的一大群美国男性和女性在8年随访期内的镁摄入量和骨折发生率。通过基线时的食物频率问卷评估饮食中的镁摄入量（包括来自补充剂的摄入量），并按性别特定的五分位数（Q）进行分类；通过自我报告的病史评估骨质疏松性骨折。总体而言，纳入了3765名参与者（1577名男性；2071名女性），平均年龄为60.6（标准差9.1）岁。在随访期间，560人（198名男性和368名女性）发生了新的骨折。在对基线时的14个潜在混杂因素进行调整后，并将镁摄入量较低的人群作为参照（Q1），最高五分位数的男性（风险比（HR）0.47；95%置信区间0.21，1.00，P=0.05）和女性（HR 0.38；95%置信区间0.17，0.82，P=0.01）报告的骨折风险显著较低。达到推荐镁摄入量的女性未来骨折风险降低27%。总之，较高的饮食镁摄入量对未来骨质疏松性骨折具有保护作用，尤其是在患膝关节骨关节炎风险较高的女性中。那些达到推荐镁摄入量的女性似乎骨折风险较低。
