Lee Ji Young, Lee Young-Jun, Park Dong Woo, Nam Yoonho, Kim Seung Hyun, Park Jinseok, Kim Young Seo, Kim Hyun Young, Oh Ki-Wook
Department of Radiology, Hanyang University Hospital, Hanyang University College of Medicine, 17 Haengdang-dong, Seongdong-gu, Seoul, 133-792, Korea.
Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Neuroradiology. 2017 Dec;59(12):1213-1222. doi: 10.1007/s00234-017-1933-9. Epub 2017 Oct 11.
The purpose of this study was to investigate the differences in motor cortex susceptibility among patients with amyotrophic lateral sclerosis (ALS), cerebrovascular disease (CVD), and healthy controls using quantitative susceptibility mapping (QSM).
We retrospectively reviewed 78 QSM images from 26 patients with ALS, 26 age- and sex-matched patients with CVD, and 26 healthy controls. A region of interest was drawn in the hand lobule of both the motor cortexes and subcortical white matter. The relative susceptibility (RS) of the motor cortex was obtained by subtracting the susceptibility of the subcortical white matter from that of the motor cortex. We compared the cortex, cortex, subcortical white matter, RS, and RS values among the three groups using analysis of variance and Tukey's post hoc test. Receiver operating characteristic (ROC) curve analysis was also performed.
There were significant differences in the cortex, cortex, RS, and RS among the three groups, with higher values in patients with ALS (p = 0.01, p = 0.004, p < 0.001, and p < 0.001, respectively). Subcortical white matter was significantly lower in patients with ALS compared with patients with CVD and healthy controls (p = 0.04). ROC curve analysis showed that the area under the curve of RS was 0.70, the highest among the measured parameters.
Quantitative measurements of susceptibility of the motor cortex with QSM demonstrate its potential as an imaging biomarker in ALS patients.
本研究旨在使用定量磁化率成像（QSM）研究肌萎缩侧索硬化症（ALS）、脑血管疾病（CVD）患者及健康对照者运动皮层磁化率的差异。
我们回顾性分析了26例ALS患者、26例年龄和性别匹配的CVD患者以及26例健康对照者的78张QSM图像。在双侧运动皮层和皮层下白质的手部小叶绘制感兴趣区。运动皮层的相对磁化率（RS）通过用运动皮层的磁化率减去皮层下白质的磁化率获得。我们使用方差分析和Tukey事后检验比较了三组之间的皮层、皮层下白质、RS及RS值。还进行了受试者工作特征（ROC）曲线分析。
三组之间的皮层、RS及RS存在显著差异，ALS患者的值更高（分别为p = 0.01、p = 0.004、p < 0.001和p < 0.001）。与CVD患者和健康对照者相比，ALS患者的皮层下白质显著更低（p = 0.04）。ROC曲线分析显示，RS的曲线下面积为0.70，在所测参数中最高。
用QSM对运动皮层磁化率进行定量测量证明了其作为ALS患者成像生物标志物的潜力。
