帕金森病患者黑质铁沉积的侧方不对称性及空间差异的定量磁化率成像测量
Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping.
作者信息
Azuma M, Hirai T, Yamada K, Yamashita S, Ando Y, Tateishi M, Iryo Y, Yoneda T, Kitajima M, Wang Y, Yamashita Y
机构信息
From the Departments of Diagnostic Radiology (M.A., M.T., Y.I., M.K., Y.Y.)
Department of Radiology (T.H.), Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
出版信息
AJNR Am J Neuroradiol. 2016 May;37(5):782-8. doi: 10.3174/ajnr.A4645. Epub 2016 Jan 28.
BACKGROUND AND PURPOSE
Quantitative susceptibility mapping is useful for assessing iron deposition in the substantia nigra of patients with Parkinson disease. We aimed to determine whether quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference in iron deposits in the substantia nigra of patients with Parkinson disease.
MATERIALS AND METHODS
Our study population comprised 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls. They underwent 3T MR imaging by using a 3D multiecho gradient-echo sequence. On reconstructed quantitative susceptibility mapping, we measured the susceptibility values in the anterior, middle, and posterior parts of the substantia nigra, the whole substantia nigra, and other deep gray matter structures in both hemibrains. To identify the more and less affected hemibrains in patients with Parkinson disease, we assessed the severity of movement symptoms for each hemibrain by using the Unified Parkinson's Disease Rating Scale.
RESULTS
In the posterior substantia nigra of patients with Parkinson disease, the mean susceptibility value was significantly higher in the more than the less affected hemibrain substantia nigra (P < .05). This value was significantly higher in both the more and less affected hemibrains of patients with Parkinson disease than in controls (P < .05). Asymmetry of the mean susceptibility values was significantly greater for patients than controls (P < .05). Receiver operating characteristic analysis showed that quantitative susceptibility mapping of the posterior substantia nigra in the more affected hemibrain provided the highest power for discriminating patients with Parkinson disease from the controls.
CONCLUSIONS
Quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease.
背景与目的
定量磁化率成像有助于评估帕金森病患者黑质中的铁沉积情况。我们旨在确定定量磁化率成像是否有助于评估帕金森病患者黑质中铁沉积的侧方不对称性和空间差异。
材料与方法
我们的研究对象包括24例帕金森病患者以及24例年龄和性别匹配的健康对照者。他们接受了3T磁共振成像检查，采用三维多回波梯度回波序列。在重建的定量磁化率成像上，我们测量了双侧大脑半球黑质前部、中部和后部、整个黑质以及其他深部灰质结构的磁化率值。为了确定帕金森病患者中受影响程度较高和较低的半脑，我们使用统一帕金森病评定量表评估了每个半脑的运动症状严重程度。
结果
在帕金森病患者的黑质后部，受影响程度较高的半脑黑质的平均磁化率值显著高于受影响程度较低的半脑黑质（P < 0.05）。帕金森病患者中受影响程度较高和较低的半脑的该值均显著高于对照组（P < 0.05）。患者平均磁化率值的不对称性显著大于对照组（P < 0.05）。受试者操作特征分析表明，受影响程度较高的半脑黑质后部的定量磁化率成像在区分帕金森病患者和对照组方面具有最高的效能。
结论
定量磁化率成像有助于评估帕金森病患者黑质中铁沉积的侧方不对称性和空间差异。
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