Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China.
State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, 550081, China.
Environ Geochem Health. 2018 Apr;40(2):903-913. doi: 10.1007/s10653-017-0033-4. Epub 2017 Oct 10.
The causes of Kashin-Beck disease (KBD) in children are multifactorial, and particular consideration has been given to childhood selenium (Se) deficiency. In this study, dietary intake of Se and mercury (Hg) was determined at KBD areas to investigate the Se status and risks. Therefore, total Hg and Se levels were investigated in scalp hair samples and in daily intake food samples of 150 schoolchildren in Yongshou County of Shaanxi, China. The results showed that the average concentration of Se in children's hair has risen to 302 ng g and significantly increased compared to the data reported decades ago. Children at KBD endemic areas likely have improved Se status due to the Se supplementation in food at recent decades. However, all the children in the study areas still showed lower Se status compared to those in other non-KBD areas of China. The probable daily intake of Se in the study areas was still lower after stopping Se supplementation in food at KBD areas, which is 17.96 μg day. Food produced locally cannot satisfy the lowest demand for Se nutrition for local residents. If the interactions of Se-Hg detoxification are considered, Hg intake from food exacerbates Se deficiency at the KBD areas.
大骨节病（KBD）患儿的病因是多因素的，尤其要考虑儿童硒（Se）缺乏。本研究在大骨节病地区测定了膳食中硒和汞（Hg）的摄入量，以调查硒的状况和风险。因此，我们对陕西省永寿县 150 名在校儿童的头皮头发样本和日常摄入食物样本中的总 Hg 和 Se 水平进行了研究。结果表明，儿童头发中的 Se 平均浓度已上升至 302ng/g，与几十年前的数据相比显著增加。由于近几十年来食物中添加了硒，大骨节病流行地区儿童的硒状况可能有所改善。然而，与中国其他非大骨节病地区相比，研究地区的所有儿童的硒状况仍然较低。在停止大骨节病地区食物中的硒补充后，研究地区的硒可能每日摄入量仍然较低，为 17.96μg/天。当地生产的食物无法满足当地居民最低的硒营养需求。如果考虑 Se-Hg 解毒的相互作用，那么从食物中摄入的 Hg 会加重大骨节病地区的 Se 缺乏。
