Costa Olívio Feitosa, Castro Rafael Bustamante, Oliveira Cibele Vasconcelos, Feitosa Thais Vieira Nogueira, Alves Josualdo Justino, Cavalcante Francisco Pimentel, Lima Marcos Venício Alves
Instituto do Câncer do Ceará, Escola Cearense de Oncologia, Fortaleza, CE, Brasil.
Rev Col Bras Cir. 2017 Jul-Aug;44(4):391-396. doi: 10.1590/0100-69912017004014.
to evaluate the risk factors for the presence of non-sentinel axillary metastatic disease in patients with breast cancer and positive sentinel node biopsy. Methods: retrospective cross-sectional study of women with breast cancer operated at the Cancer Institute of Ceará between 2002 and 2012 and submitted to sentinel lymph node biopsy.
Among 946 breast cancer patients, 331 underwent sentinel lymph node biopsy, which was positive in 83. These patients underwent axillary lymphadenectomy and 39 (46%) had metastases in other axillary lymph nodes. The variables that were significant for additional axillary disease included Ki67>14 (p=0.043), angiolymphatic invasion (p=0.01) and tumor size (p=0.027). No association was observed with estrogen, progesterone, tumor grade and Her-2 receptors.
the presence of angiolymphatic invasion and tumor size have also been related to additional axillary metastasis in other studies. In addition to these variables, the same predictive effect was observed when we evaluated Ki67. The validation of these results may allow the customization of breast cancer treatment, which may reduce its morbidity.
angiolymphatic invasion, tumor size (T3/T4) and Ki67>14 were factors predictive of axillary metastasis involvement in addition to the sentinel lymph node.
评估乳腺癌患者前哨淋巴结活检阳性时出现非前哨腋窝转移疾病的风险因素。方法：对2002年至2012年在塞阿拉癌症研究所接受手术并进行前哨淋巴结活检的乳腺癌女性患者进行回顾性横断面研究。
在946例乳腺癌患者中，331例接受了前哨淋巴结活检，其中83例为阳性。这些患者接受了腋窝淋巴结清扫术，39例（46%）在其他腋窝淋巴结有转移。对额外腋窝疾病有显著意义的变量包括Ki67>14（p=0.043）、血管淋巴管浸润（p=0.01）和肿瘤大小（p=0.027）。未观察到与雌激素、孕激素、肿瘤分级和Her-2受体的关联。
在其他研究中，血管淋巴管浸润和肿瘤大小的存在也与额外的腋窝转移有关。除了这些变量外，我们评估Ki67时也观察到了相同的预测效果。这些结果的验证可能允许定制乳腺癌治疗方案，从而降低其发病率。
血管淋巴管浸润、肿瘤大小（T3/T4）和Ki67>14是除前哨淋巴结外腋窝转移受累的预测因素。
