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采用美罗培南联合磷霉素治疗产超广谱β-内酰胺酶和氟喹诺酮耐药伤寒沙门氏菌感染取得成功。

Successful Therapy of a Multidrug-Resistant Extended-Spectrum β-Lactamase-Producing and Fluoroquinolone-Resistant Salmonella enterica Subspecies enterica Serovar Typhi Infection Using Combination Therapy of Meropenem and Fosfomycin.

机构信息

Department of Internal Medicine I, University Hospital of Bonn.

German Center of Infection Research, Partner site Cologne-Bonn.

出版信息

Clin Infect Dis. 2017 Oct 30;65(10):1754-1756. doi: 10.1093/cid/cix652.

DOI:10.1093/cid/cix652
PMID:29020162
Abstract

We report a traveler who acquired a Salmonella enterica subspecies enterica serovar Typhi strain with resistance against β-lactams, cephalosporins (extended-spectrum β-lactamase-producing type SHV-12), and quinolones (plasmid-mediated quinolone resistance gene qnrB7). After clinical deterioration using meropenem monotherapy, treatment success was achieved after commencement of fosfomycin in conjunction with high-dose meropenem. The case illustrates clinical challenges of multidrug-resistant S. Typhi.

摘要

我们报告了一位旅行者感染了对β-内酰胺类、头孢菌素类（产生型 SHV-12 的扩展谱β-内酰胺酶）和喹诺酮类药物（质粒介导的喹诺酮类耐药基因 qnrB7）具有耐药性的肠炎沙门氏菌亚种肠炎血清型 Typhi 菌株。在使用美罗培南单药治疗病情恶化后，联合使用磷霉素和高剂量美罗培南后治疗成功。该病例说明了多重耐药性伤寒沙门氏菌的临床挑战。

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