a Advanced Eye Center, Post Graduate Institute of Medical Education and Research , Chandigarh , India.
b National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore.
Ocul Immunol Inflamm. 2018;26(6):838-844. doi: 10.1080/09273948.2017.1370650. Epub 2017 Oct 11.
To assess choroidal vascular changes among patients with tubercular multifocal serpiginoid choroiditis (TB MSC) using previously validated techniques.
Patients with TB MSC (n = 18) and healthy controls (n = 30) underwent enhanced-depth imaging optical coherence tomography (EDI-OCT) imaging. Using previously validated algorithm of image binarization, EDI-OCT scans were segmented to derive total choroidal area, luminal area, stromal area, and choroidal vascularity index (CVI).
There was a statistically significant difference in the CVI between controls (66.90 ± 1.77%) and TB MSC patients (65.46 ± 2.53%; p < 0.001). There was significant reduction in CVI at follow-up (3 months) (63.77 ± 3.91%; p = 0.05). The choroidal thickness was higher in TB MSC compared to controls (278.90 ± 57.84 µm versus 329.33 ± 27.69 µm; p = 0.001).
CVI provides insight into structural changes in choroid in TB MSC. During the active disease, there is relative decrease in choroidal vascularity. As the lesions heal, choriocapillaris atrophy occurs with remodeling of choroid.
利用已验证的技术评估结核性多灶性匐行性脉络膜视网膜炎（TB MSC）患者的脉络膜血管变化。
对 18 例 TB MSC 患者（TB MSC 组）和 30 例健康对照者（对照组）进行增强深度成像光学相干断层扫描（EDI-OCT）成像。使用先前验证的图像二值化算法，对 EDI-OCT 扫描进行分割，以得出总脉络膜面积、管腔面积、基质面积和脉络膜血管指数（CVI）。
对照组（66.90±1.77%）和 TB MSC 患者（65.46±2.53%；p<0.001）的 CVI 存在统计学差异。在随访（3 个月）时 CVI 显著降低（63.77±3.91%；p=0.05）。与对照组相比，TB MSC 患者的脉络膜厚度更高（278.90±57.84 µm 与 329.33±27.69 µm；p=0.001）。
CVI 提供了 TB MSC 脉络膜结构变化的见解。在疾病活跃期，脉络膜血管密度相对降低。随着病变愈合，脉络膜毛细血管萎缩并发生重塑。
