Department of Nephrology, Xijing Hospital, the Fourth Military Medical University, Xian, China.
Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; and.
Physiology (Bethesda). 2017 Nov;32(6):453-463. doi: 10.1152/physiol.00016.2017.
For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize key findings of lactic acid signaling, functions, and many remaining questions.
几十年来，乳酸一直被认为是糖酵解的终产物。过去 20 多年的研究表明并非如此。通过其转运蛋白（MCTs）和受体（GPR81），乳酸在多种细胞过程中发挥关键作用，包括能量调节、免疫耐受、记忆形成、伤口愈合、缺血组织损伤以及癌症生长和转移。我们总结了乳酸信号传递、功能的关键发现以及许多仍然存在的问题。
