Rahman Nurasyikin Abdul, Ngaini Zainab, Farooq Saba, Ai Ling Sabrina Chua, Shahren Puteri Nabilah Jefree
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, 94300, Malaysia.
Malaysian Pepper Board, 93916, Kuching, Sarawak, Malaysia.
Bioresour Bioprocess. 2025 Jul 29;12(1):81. doi: 10.1186/s40643-025-00923-3.
The increasing demand for lactic acid (LA), driven by its applications in biodegradable plastics, food additives, pharmaceuticals, and cosmetics, necessitates the development of sustainable production methods. Traditional processes often rely on food-based feedstock, aggravating food security concerns. This review addresses the critical gap in utilising agricultural waste as a non-food feedstock for LA production, thereby reducing waste and promoting a circular economy. Current techniques are thoroughly explored, including fed-batch, batch, and continuous fermentation procedures, as well as the utilisation of various microbial strains, including Lactobacillus species. Recent developments in genetic engineering and innovative fermentation techniques are discussed, alongside challenges such as substrate variability and contamination. By highlighting the potential of agricultural residues, such as sugarcane bagasse, rice husk and corn stover, this review provides a roadmap for future research and industrial applications to enhance sustainability and efficiency in LA production.
乳酸（LA）在生物可降解塑料、食品添加剂、药品和化妆品中的应用推动了其需求的不断增长，这就需要开发可持续的生产方法。传统工艺通常依赖于以粮食为基础的原料，加剧了粮食安全问题。本综述解决了利用农业废弃物作为生产LA的非粮食原料这一关键差距，从而减少废弃物并促进循环经济。对当前技术进行了全面探索，包括分批补料、分批和连续发酵程序，以及各种微生物菌株的利用，包括乳酸杆菌属。讨论了基因工程和创新发酵技术的最新进展，以及底物变异性和污染等挑战。通过强调甘蔗渣、稻壳和玉米秸秆等农业残余物的潜力，本综述为未来的研究和工业应用提供了路线图，以提高LA生产的可持续性和效率。
