Lee Seungyeop, Rhee Dong-Kwon
School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Su-Won 16419, Republic of Korea.
J Ginseng Res. 2017 Oct;41(4):589-594. doi: 10.1016/j.jgr.2017.01.010. Epub 2017 Jan 24.
Ginseng effectively regulates the immune response and the hormonal changes due to stress, thus maintaining homeostasis. In addition to suppressing the occurrence of psychological diseases such as anxiety and depression, ginseng also prevents stress-associated physiological diseases. Recent findings have revealed that ginseng is involved in adjusting the hypothalamic-pituitary-adrenal axis and controlling hormones, thus producing beneficial effects on the heart and brain, and in cases of bone diseases, as well as alleviating erectile dysfunction. Recent studies have highlighted the potential use of ginseng in the prevention and treatment of chronic inflammatory diseases such as diabetes, rheumatoid arthritis, and allergic asthma. However, the mechanism underlying the effects of ginseng on these stress-related diseases has not been completely established. In this review, we focus on the disease pathways caused by stress in order to determine how ginseng acts to improve health. Central to our discussion is how this effective and stable therapeutic agent alleviates the anxiety and depression caused by stress and ameliorates inflammatory diseases.
人参能有效调节因压力引起的免疫反应和激素变化，从而维持体内平衡。除了抑制焦虑和抑郁等心理疾病的发生外，人参还能预防与压力相关的生理疾病。最近的研究发现表明，人参参与调节下丘脑 - 垂体 - 肾上腺轴并控制激素，从而对心脏和大脑产生有益影响，在骨骼疾病中也是如此，还能缓解勃起功能障碍。最近的研究突出了人参在预防和治疗糖尿病、类风湿性关节炎和过敏性哮喘等慢性炎症性疾病方面的潜在用途。然而，人参对这些与压力相关疾病的作用机制尚未完全明确。在本综述中，我们聚焦于由压力引发的疾病途径，以确定人参改善健康的作用方式。我们讨论的核心是这种有效且稳定的治疗剂如何减轻压力引起的焦虑和抑郁，并改善炎症性疾病。
