Mx流感病毒抗性基因在小鼠16号染色体上与人类21号染色体同源区域内的遗传定位。
Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21.
作者信息
Reeves R H, O'Hara B F, Pavan W J, Gearhart J D, Haller O
机构信息
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
出版信息
J Virol. 1988 Nov;62(11):4372-5. doi: 10.1128/JVI.62.11.4372-4375.1988.
Abstract
A total of 318 progeny from four backcrosses involving different laboratory strains and subspecies of Mus musculus were analyzed to map the Mx gene to the region of mouse chromosome 16 (MMU 16) which is homologous to human chromosome 21 (HSA 21). This result suggests that Mx will be found in the region of HSA 21 which has been implicated in Down syndrome when inherited in three copies.
摘要
对涉及小家鼠不同实验室品系和亚种的四个回交产生的总共318个后代进行了分析，以将Mx基因定位到小鼠16号染色体（MMU 16）上与人类21号染色体（HSA 21）同源的区域。这一结果表明，Mx基因将在HSA 21区域被发现，该区域在三倍体遗传时与唐氏综合征有关。
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