Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, United States.
Curr Opin Virol. 2013 Oct;3(5):531-6. doi: 10.1016/j.coviro.2013.07.005. Epub 2013 Aug 8.
Despite effective vaccines, influenza remains a major global health threat due to the morbidity and mortality caused by seasonal epidemics, as well as the 2009 pandemic. Also of profound concern are the rare but potentially catastrophic transmissions of avian influenza to humans, highlighted by a recent H7N9 influenza outbreak. Murine and human studies reveal that the clinical course of influenza is the result of a combination of both host and viral genetic determinants. While viral pathogenicity has long been the subject of intensive efforts, research to elucidate host genetic determinants, particularly human, is now in the ascendant, and the goal of this review is to highlight these recent insights.
尽管有有效的疫苗，但流感仍然是一个主要的全球健康威胁，因为季节性流行和 2009 年大流行会导致发病率和死亡率，以及罕见但潜在灾难性的禽流感向人类传播，最近的 H7N9 流感爆发就是一个突出的例子。鼠类和人类研究表明，流感的临床病程是宿主和病毒遗传决定因素共同作用的结果。虽然病毒的致病性一直是密集研究的主题，但阐明宿主遗传决定因素，特别是人类的研究现在正在兴起，本综述的目的是强调这些最新的见解。
