Tan Y H, Schneider E L, Tischfield J, Epstein C J, Ruddle F H
Science. 1974 Oct 4;186(4158):61-3. doi: 10.1126/science.186.4158.61.
Human primary skin fibroblasts trisomic for chromosome 13, 18, or 21 and diploid human skin fibroblasts were induced for an antiviral response with human interferon. The cells that were trisomnic for chromosome 21 were three to seven times more sensitive to protection by human interferon than the normal diploid or trisomic 18 or 13 fibroblasts. The differential response in trisomnic 21 cells is consistent with the known assignment of the human antiviral gene to chromosome 21.
对13号、18号或21号染色体三体的人原发性皮肤成纤维细胞以及二倍体人皮肤成纤维细胞用人干扰素诱导其产生抗病毒反应。21号染色体三体的细胞对人干扰素保护作用的敏感性比正常二倍体或18号或13号染色体三体的成纤维细胞高3至7倍。21号染色体三体细胞中的这种差异反应与已知的人类抗病毒基因定位于21号染色体相符。
