来自光亮马钱子的新型吡啶并咔唑生物碱。
New pyridocarbazole alkaloids from Strychnos nitida.
作者信息
Li Wei, Tang Gui-Hua, Chen Lin, Tang Ya-Qi, Xu You-Kai, Liu Bo, Yin Sheng
机构信息
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
b Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden , Chinese Academy of Sciences , Menglun , China.
出版信息
Nat Prod Res. 2018 Jul;32(13):1532-1536. doi: 10.1080/14786419.2017.1385016. Epub 2017 Oct 12.
Phytochemical investigation of Strychnos nitida has led to the isolation of three new racemic pyridocarbazole alkaloids, (±)-stritidas A-C (1-3) and three known monoterpenoid indole alkaloids (4-6). Compounds 2 and 3 represent the first examples of pyridocarbazole alkaloids featuring an N-2-hydroxyethyl moiety. Their structures were determined by combined spectroscopic data (MS, UV, IR and NMR) and chemical methods.
对光亮马钱（Strychnos nitida）进行植物化学研究，已分离出三种新的外消旋吡啶并咔唑生物碱，即（±）-斯特里蒂达斯A-C（1-3）以及三种已知的单萜吲哚生物碱（4-6）。化合物2和3是具有N-2-羟乙基部分的吡啶并咔唑生物碱的首例。通过综合光谱数据（质谱、紫外光谱、红外光谱和核磁共振）及化学方法确定了它们的结构。
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