4,5-二氢恶唑衍生物对碱基生成的 -醌甲醚的亲核加成：四组分反应。

Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106-9510, United States.

J Org Chem. 2023 Feb 17;88(4):2583-2588. doi: 10.1021/acs.joc.2c02614. Epub 2023 Jan 31.

A novel method for joining components together in a single pot leading to an assortment of N-amino-benzylated phenols is described. The method involves the addition of different Grignard reagents to various -OBoc salicylaldehydes in the presence of assorted 4,5-dihydrooxazoles, followed by aqueous workup. Seventeen examples are presented with varied (-R, -R' -R″, -R‴, -R⁗, and C) substituents.

描述了一种在单个锅中将组件连接在一起的新方法，可得到各种 N-氨甲基化的苯并酚。该方法包括在各种 -OBoc 水杨醛存在下，向不同的格氏试剂中添加各种 4,5-二氢恶唑，然后进行水相处理。提供了 17 个示例，其中包含不同的取代基（-R、-R'、-R″、-R‴、-R⁗和 C）。