Isaksson Jenny, Carlsson Ola, Airell Åsa, Strömdahl Susanne, Bratt Göran, Herrmann Björn
Department of Medical Sciences, Section of Clinical Bacteriology, Uppsala University, Uppsala, Sweden.
Department of Clinical Bacteriology, Karolinska University Hospital Huddinge, Stockholm, Sweden.
J Med Microbiol. 2017 Nov;66(11):1684-1687. doi: 10.1099/jmm.0.000597. Epub 2017 Oct 12.
This study aimed to determine the incidence of lymphogranuloma venereum (LGV) in Sweden since 2004 and to study in detail a consecutive number of Chlamydia trachomatis cases in men who have sex with men (MSM) during a 10 month period (September 2014 to July 2015). LGV increased from sporadic import cases in 2004 to comprise a spread within Sweden in 2016. Initially, only the L2b ompA genotype was detected, but in 2015 half of the genotyped LGV cases were L2 genotype. The changing genotype distribution in Sweden is linked to increased LGV spread in Europe. High-resolution multilocus sequence typing of 168 C. trachomatis cases from MSM in 2015 resulted in 29 sequence types, of which 3 accounted for 49 % of cases. The increased rates and different genotypes of LGV indicate that more concern for high-risk taking MSM is needed to avoid further spread of this invasive infection.
本研究旨在确定自2004年以来瑞典性病性淋巴肉芽肿（LGV）的发病率，并详细研究在2014年9月至2015年7月这10个月期间男男性行为者（MSM）中连续出现的沙眼衣原体病例数。LGV从2004年的散发性输入病例增加到2016年在瑞典境内传播。最初，仅检测到L2b ompA基因型，但在2015年，分型的LGV病例中有一半为L2基因型。瑞典不断变化的基因型分布与欧洲LGV传播增加有关。对2015年来自MSM的168例沙眼衣原体病例进行的高分辨率多位点序列分型产生了29种序列类型，其中3种占病例的49%。LGV发病率的增加和不同的基因型表明，需要更加关注高危MSM，以避免这种侵袭性感染的进一步传播。
