Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.
J Am Chem Soc. 2017 Oct 25;139(42):14833-14836. doi: 10.1021/jacs.7b07518. Epub 2017 Oct 12.
Experimental and computational studies pertaining to the Fischer azaindolization reaction are reported. These studies explain why pyridylhydrazines are poorly reactive in Fischer indolization reactions, in addition to the origin of hydrazine substituent effects. Additionally, an interrupted variant of Fischer azaindolization methodology is disclosed, which provides a synthetic entryway into fused azaindoline scaffolds.
报告了与 Fischer 氮茚化反应相关的实验和计算研究。这些研究解释了为什么吡啶基腙在 Fischer 吲哚化反应中反应性差，以及肼取代基效应的起源。此外，还公开了 Fischer 氮茚化方法的中断变体，该变体为融合氮茚骨架提供了合成途径。
