经产妇与未产妇及初产妇相比对胰岛素、血糖水平和胰岛素抵抗指数的影响。

Influence of Grand Multiparity on the Levels of Insulin, Glucose and HOMA-IR in Comparison with Nulliparity and Primiparity.

作者信息

Eldin Ahmed Abdelsalam Kamal, Alobeid M Elamin Abdelsamee

机构信息

Department of Chemical Pathology, College of Applied Medical Sciences, Shaqra University, Saudi Arabia.

Department of Clinical Biochemistry, College of Applied Medical Sciences, Shaqra University, Saudi Arabia.

出版信息

Pak J Biol Sci. 2017;20(1):42-46. doi: 10.3923/pjbs.2017.42.46.

DOI:10.3923/pjbs.2017.42.46

PMID:29023014

Abstract

OBJECTIVE

It is to compare the levels of fasting glucose and insulin as well as insulin resistance in grand multiparas with primiparity and nulliparity.

METHODOLOGY

Fasting blood samples were collected from 100 non-pregnant ladies as control group, 100 primiparity pregnant women and 100 grand multiparity pregnant women. Glucose (FBS) and insulin (FSI) concentrations were measured by Hitachi 912 full automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer procedure. Insulin resistance was calculated following the formula: FBG (mg dL-1)×FSI (μU mL-1)/405.

RESULTS

This study found a significant reduction in glucose level in primiparity when compared to control group but it was increased significantly in multiparity comparing to primiparity and control. Insulin level showed significant high concentrations in pregnant women and increased significantly in grand multiparas comparing to primiparas and controls. As a result of that, HOMA-IR was increased significantly by increasing of parity. Also, there was a significant increase in fasting insulin and a decrease in insulin sensitivity with parity with association to age and obesity.

CONCLUSION

Grand multiparity is associated with an increased risk of subsequent clinical insulin resistance (HOMA-IR).

摘要

目的

比较经产妇与初产妇及未产妇的空腹血糖、胰岛素水平以及胰岛素抵抗情况。

方法

采集100名未孕女性作为对照组、100名初产妇和100名经产妇的空腹血样。按照制造商操作流程，使用日立912全自动化学分析仪（德国罗氏诊断公司）测量血糖（空腹血糖）和胰岛素（空腹胰岛素）浓度。按照公式：空腹血糖（mg/dL）×空腹胰岛素（μU/mL）/405计算胰岛素抵抗。

结果

本研究发现，与对照组相比，初产妇的血糖水平显著降低，但与初产妇和对照组相比，经产妇的血糖水平显著升高。孕妇的胰岛素水平显示出显著的高浓度，与初产妇和对照组相比，经产妇的胰岛素水平显著升高。因此，随着产次增加，稳态模型评估胰岛素抵抗（HOMA-IR）显著增加。此外，空腹胰岛素随着产次增加而显著升高，胰岛素敏感性随着产次增加而降低，且与年龄和肥胖有关。