产次与 2 型糖尿病之间的关联：一项基于社区的横断面研究。
The association between parity and type 2 diabetes mellitus: a cross-sectional, community-based study.
机构信息
Royal Commission Hospital at AL Jubail Industrial City, Al Jubail, Kingdom of Saudi Arabia.
Faculty of Medicine, Alneelain University, Khartoum, Sudan.
出版信息
BMC Endocr Disord. 2024 Oct 31;24(1):233. doi: 10.1186/s12902-024-01767-2.
BACKGROUND
Limited published data exist on the association between parity (number of deliveries) and diabetes mellitus (DM). This study was conducted to evaluate the association between parity and type 2 DM (T2DM) among Sudanese women.
METHOD
A multistage sampling survey was conducted in four villages in the River Nile State, Sudan, between July and September 2022. The World Health Organization's three-level stepwise questionnaire was adopted to collect women's sociodemographic characteristics (age, sex, height, weight, marital status, parity, education level, occupation, detailed obstetric history, and family history of T2DM). Multivariate analyses were performed.
RESULTS
A total of 397 women were recruited. Their median (interquartile range) age was 45.0 (33.0‒55.7) years. A total of 154 women (38.8%) were nulliparous, whereas 93 (23.4%), 70 (17.6%), and 80 (20.2%) had para 1‒3, 4 or 5, and more than 5, respectively. A total of 112 (28.2%) women had T2DM. In multivariate analysis, older age (adjusted odds ratio, AOR, 1.04, 95%, confidence interval, CI, 1.02‒1.06), high parity (AOR, 1.1, 95% C, 1.01‒1.20), and a family history of DM (AOR, 3.26, 95% CI, 1.98‒5.38) were associated with T2DM. Compared with the nulliparity, para 1‒3 (AOR, 2.33; 95% CI, 1.17‒4.61), para 4 or 5 (AOR, 2.12; 95% CI, 1.04‒4.30), and para > 5 (AOR, 2.16; 95% CI, 1.09‒4.27) were at higher risk of T2DM. In women aged < 50 years, high parity (AOR, 1.22; 95% CI, 1.06‒1.44) was associated with T2DM. Compared with the nulliparous women, para 4 or 5 (AOR, 3.47; 95% CI, 1.16‒10.34) and para > 5 (AOR, 4.63; 95% CI, 1.54‒13.87) were associated with T2DM, whereas para 1‒3 was not associated with T2DM. In the women aged ≥ 50 years, parity and parity groups were not associated with T2DM.
CONCLUSION
There is a high prevalence of T2DM among Sudanese women. Parity and high parity are significant predictors of T2DM among these women in this part of Sudan.
背景
关于生育次数（分娩次数）与糖尿病（DM）之间的关联，已有有限的文献报道。本研究旨在评估生育次数与苏丹女性 2 型糖尿病（T2DM）之间的关系。
方法
2022 年 7 月至 9 月，在苏丹尼罗州的四个村庄进行了多阶段抽样调查。采用世界卫生组织的三级逐步式问卷收集了女性的社会人口统计学特征（年龄、性别、身高、体重、婚姻状况、生育次数、教育程度、职业、详细的产科史和 T2DM 家族史）。进行了多变量分析。
结果
共纳入 397 名女性，其年龄中位数（四分位间距）为 45.0（33.0‒55.7）岁。154 名女性（38.8%）为未产妇，93 名（23.4%）、70 名（17.6%）和 80 名（20.2%）分别为生育 1‒3 次、4 次或 5 次和 5 次以上。共有 112 名（28.2%）女性患有 T2DM。多变量分析显示，年龄较大（调整后的优势比，AOR，1.04，95%置信区间，CI，1.02‒1.06）、生育次数较高（AOR，1.1，95%CI，1.01‒1.20）和糖尿病家族史（AOR，3.26，95%CI，1.98‒5.38）与 T2DM 相关。与未产妇相比，生育 1‒3 次（AOR，2.33；95%CI，1.17‒4.61）、生育 4 次或 5 次（AOR，2.12；95%CI，1.04‒4.30）和生育次数大于 5 次（AOR，2.16；95%CI，1.09‒4.27）的女性患 T2DM 的风险更高。在年龄小于 50 岁的女性中，高生育次数（AOR，1.22；95%CI，1.06‒1.44）与 T2DM 相关。与未产妇相比，生育 4 次或 5 次（AOR，3.47；95%CI，1.16‒10.34）和生育次数大于 5 次（AOR，4.63；95%CI，1.54‒13.87）与 T2DM 相关，而生育 1‒3 次与 T2DM 无关。在年龄大于等于 50 岁的女性中，生育次数和生育次数组与 T2DM 无关。
结论
苏丹女性中 T2DM 的患病率较高。生育次数和高生育次数是这些女性患 T2DM 的重要预测因素。
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