Larsen R, Sandhu N, Heegaard N H H, Ullum H, von Stemann J H, Sørensen E, Nellemann D S, Hansen M B
Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark.
Department of Congenital Diseases, Statens Serum Institut, Copenhagen, Denmark.
Vox Sang. 2018 Jan;113(1):76-79. doi: 10.1111/vox.12607. Epub 2017 Oct 11.
It would be desirable to be able to distinguish fever as a result of febrile non-haemolytic transfusion reactions (FNHTR) from other febrile conditions. To further characterize the inflammatory feature of FNHTR, we measured a large panel of inflammatory markers in pre- and posttransfusion plasma samples from patients with and without FNHTR following the transfusion of leucoreduced red blood cells. As FNHTR patients only displayed a significant increase in IL-6, we conclude that changes in plasma cytokine levels during FNHTR are unlikely to be used diagnostically. An incidental finding of a distinct cytokine pattern in pretransfusion samples from FNHTR patients warrants further investigations, as it might be used to characterize the nature of FNHTR and to predict the risk of these adverse events.
能够将发热性非溶血性输血反应（FNHTR）导致的发热与其他发热情况区分开来是很有必要的。为了进一步表征FNHTR的炎症特征，我们在输注白细胞滤除红细胞后，对有和没有FNHTR的患者输血前和输血后的血浆样本中大量的炎症标志物进行了测量。由于FNHTR患者仅表现出IL-6显著升高，我们得出结论，FNHTR期间血浆细胞因子水平的变化不太可能用于诊断。FNHTR患者输血前样本中存在独特的细胞因子模式这一偶然发现值得进一步研究，因为它可能用于表征FNHTR的性质并预测这些不良事件的风险。
