Neumann J, Schmitz W, Scholz H, von Meyerinck L, Döring V, Kalmar P
Department of Pharmacology, Universitäts-Krankenhaus Eppendorf, University of Hamburg, West Germany.
Lancet. 1988 Oct 22;2(8617):936-7. doi: 10.1016/s0140-6736(88)92601-3.
The contractile response and myocardial content of Gi-proteins were examined in cardiac preparations from explanted hearts of four different patients with end-stage heart failure. Three patients had idiopathic dilated cardiomyopathy and one patient had inflammatory heart disease. Preparations from patients with idiopathic dilated cardiomyopathy showed reduced contractile response to the cAMP-increasing agent isoprenaline and an increase in myocardial Gi-proteins, compared with preparations from non-failing hearts. Therefore it is conceivable that an increase in myocardial Gi-proteins is causally related to heart failure due to idiopathic dilated cardiomyopathy. In the preparation from the patient with inflammatory heart disease the contractile response to isoprenaline was not reduced and likewise content of Gi-proteins was not changed.
在取自4名终末期心力衰竭患者离体心脏的心脏标本中，检测了Gi蛋白的收缩反应和心肌含量。3名患者患有特发性扩张型心肌病，1名患者患有炎症性心脏病。与非衰竭心脏的标本相比，特发性扩张型心肌病患者的标本对增加cAMP的药物异丙肾上腺素的收缩反应降低，且心肌Gi蛋白增加。因此，可以推测心肌Gi蛋白的增加与特发性扩张型心肌病导致的心力衰竭存在因果关系。在炎症性心脏病患者的标本中，对异丙肾上腺素的收缩反应未降低，Gi蛋白含量同样未改变。
