Neuroscience Program, Wellesley College, Wellesley, MA, USA.
Neuroscience Institute, Georgia State University, Atlanta, GA, USA.
J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12548.
It is becoming well established that the gut microbiome has a profound impact on human health and disease. In this review, we explore how steroids can influence the gut microbiota and, in turn, how the gut microbiota can influence hormone levels. Within the context of the gut microbiome-brain axis, we discuss how perturbations in the gut microbiota can alter the stress axis and behaviour. In addition, human studies on the possible role of gut microbiota in depression and anxiety are examined. Finally, we present some of the challenges and important questions that need to be addressed by future research in this exciting new area at the intersection of steroids, stress, gut-brain axis and human health.
越来越多的证据表明，肠道微生物组对人类健康和疾病有着深远的影响。在这篇综述中，我们探讨了类固醇如何影响肠道微生物组，以及肠道微生物组如何反过来影响激素水平。在肠道微生物组-大脑轴的背景下，我们讨论了肠道微生物组的紊乱如何改变应激轴和行为。此外，我们还研究了人类肠道微生物群在抑郁症和焦虑症中可能发挥的作用。最后，我们提出了在这一令人兴奋的新领域中，未来研究需要解决的一些挑战和重要问题，该领域涉及类固醇、应激、肠道-大脑轴和人类健康的交叉点。
