Department of Prosthodontics, School of Stomatology, Capital Medical University, Beijing, 100050, China.
Reproductive and GeneticNational Research Institute for Family Planning, Beijing, 100081, China.
J Biomed Mater Res B Appl Biomater. 2018 Aug;106(6):2131-2139. doi: 10.1002/jbm.b.34020. Epub 2017 Oct 10.
The research on artificial nerve conduits has become a focus of study in peripheral nerve reconstruction so as a possible replacement for the treatment of autologous nerve grafts in clinics. In this study, we used longitudinally oriented collagen conduit (LOCC) combined with nerve growth factor (NGF) to reconstruct long distance of sciatic nerve defects (35 mm) in adult dog model. The long term follow-up evaluation demonstrated that the LOCC/NGF conduit allowed functional and morphological nerve regeneration at the transection site of the injured sciatic nerve. Furthermore, the functional study confirmed that when NGF was loaded onto LOCC it promoted a better recovery of regenerated axons than LOCC alone. The gastrocnemius muscle mass in the LOCC/NGF group was significantly greater than in the LOCC alone group. The results indicated that when LOCC conduit combined with NGF it would provide a preferential environment for sciatic nerve regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2131-2139, 2018.
神经导管的研究已成为周围神经重建的研究热点，有望替代临床中自体神经移植的治疗方法。本研究采用定向胶原导管（LOCC）联合神经生长因子（NGF）修复成年犬模型 35mm 长的坐骨神经缺损。长期随访评估表明，LOCC/NGF 导管可使损伤坐骨神经的横断部位实现功能和形态学神经再生。此外，功能研究证实，当 NGF 加载到 LOCC 上时，与 LOCC 单独使用相比，再生轴突的恢复更好。LOCC/NGF 组的比目鱼肌质量明显大于 LOCC 单独组。结果表明，当 LOCC 导管与 NGF 结合使用时，可为坐骨神经再生提供有利环境。 © 2017 Wiley Periodicals, Inc. J 生物材料研究杂志 B：应用生物材料，106B：2131-2139，2018。
