Department of Materials Science, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India.
Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai 625 021, India.
Mater Sci Eng C Mater Biol Appl. 2018 Jan 1;82:182-189. doi: 10.1016/j.msec.2017.08.058. Epub 2017 Aug 12.
Curcumin loaded ZnO nanoparticles were successfully synthesised and encapsulated with co-polymer PMMA-AA (Cur/PMMA-AA/ZnO NPs). The ZnO nanoparticles have been converted as good cargo materials to carry the well-known hydrophobic drug curcumin by surface functionalization. Physical characteristics of these novel nanomaterials have been studied with transmission electron microscopy (TEM) and powder X-ray diffraction (XRD) in conjunction with spectral techniques. A narrow particle size distribution with an average value of 42nm was found via TEM. Most importantly, the pH-responsive release of curcumin from the nano-vehicle ensures safer, more controlled delivery of the drug at physiological pH. The drug entrapment efficiency and loading was evaluated and the in vitro efficacy as anticancer drug delivery vehicle was analyzed. The potential toxicity of Cur/PMMA-AA/ZnO NPs was studied by using AGS gastric cancer cell lines via MTT assay. These results revealed that the proposed nanomaterials induce a remarkable cell death in in-vitro models. The multifunctional properties of Cur/PMMA-AA/ZnO NPs may open up new avenues in cancer therapy through overcoming the limitations of conventional cancer therapy.
负载姜黄素的氧化锌纳米粒子成功合成，并与共聚物 PMMA-AA（Cur/PMMA-AA/ZnO NPs）进行了封装。通过表面功能化，将氧化锌纳米粒子转化为携带知名疏水性药物姜黄素的良好载药材料。利用透射电子显微镜（TEM）和粉末 X 射线衍射（XRD）以及光谱技术研究了这些新型纳米材料的物理特性。TEM 发现平均粒径为 42nm 的窄粒径分布。最重要的是，纳米载体中姜黄素的 pH 响应性释放确保了在生理 pH 下更安全、更受控的药物输送。评估了药物包封效率和载药量，并分析了作为抗癌药物递送载体的体外功效。通过 MTT 测定法，使用 AGS 胃癌细胞系研究了 Cur/PMMA-AA/ZnO NPs 的潜在毒性。这些结果表明，所提出的纳米材料在体外模型中诱导了显著的细胞死亡。Cur/PMMA-AA/ZnO NPs 的多功能特性可能通过克服传统癌症治疗的局限性，为癌症治疗开辟新途径。
