Digestive and Liver Disease Unit, S. Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Medical Oncology Unit, Istituto Nazionale Tumori Regina Elena (IFO), Rome, Italy.
Sci Rep. 2017 Oct 12;7(1):13024. doi: 10.1038/s41598-017-13430-z.
Data on the association between aspirin and statin use and Pancreatic Ductal AdenoCarcinoma (PDAC) risk are conflicting. These drugs are often co-prescribed, but no studies evaluated the potential combined or confounding effect of the two at the same time. We aimed to investigate the association between aspirin and statin exclusive and combined use and PDAC occurrence. Data on environmental factors, family and medical history were screened in a case-control study. PDAC cases were matched to controls for age and gender. Power calculation performed ahead. Odds ratios (OR) and 95% confidence intervals(CI) were obtained from multivariable logistic regression analysis. In 408 PDAC patients and 816 matched controls, overall statin (OR 0.61; 95%CI,0.43-0.88), but not aspirin use was associated to reduced PDAC risk. Compared to non-users, exclusive statin (OR 0.51; 95%CI,0.32-0.80) and exclusive aspirin users (OR 0.64; 95%CI,0.40-1.01) had reduced PDAC risk. Concomitant statin and aspirin use did not further reduce the risk compared with statin use alone and no interaction was evident. Statin protective association was dose-dependent, and consistent in most subgroups, being stronger in smokers, elderly, obese and non-diabetic patients. The present study suggests that statin use is associated to reduced PDAC risk, supporting a chemopreventive action of statins on PDAC.
关于阿司匹林和他汀类药物的使用与胰腺导管腺癌（PDAC）风险之间的关联，数据存在冲突。这两种药物经常同时开具，但尚无研究评估同时使用这两种药物的潜在联合或混杂作用。我们旨在研究阿司匹林和他汀类药物单独和联合使用与 PDAC 发生之间的关系。在一项病例对照研究中筛选了环境因素、家族和病史数据。PDAC 病例与对照按年龄和性别匹配。提前进行了功效计算。多变量逻辑回归分析得出比值比（OR）和 95%置信区间（CI）。在 408 例 PDAC 患者和 816 例匹配对照中，总体他汀类药物（OR 0.61；95%CI，0.43-0.88），而不是阿司匹林的使用与降低 PDAC 风险相关。与非使用者相比，单独使用他汀类药物（OR 0.51；95%CI，0.32-0.80）和单独使用阿司匹林的患者（OR 0.64；95%CI，0.40-1.01）降低了 PDAC 风险。与单独使用他汀类药物相比，同时使用他汀类药物和阿司匹林并没有进一步降低风险，并且没有明显的相互作用。他汀类药物的保护作用呈剂量依赖性，在大多数亚组中一致，在吸烟者、老年人、肥胖者和非糖尿病患者中作用更强。本研究表明，他汀类药物的使用与降低 PDAC 风险相关，支持他汀类药物对 PDAC 的化学预防作用。
